AML1/ETO

AML 1 gene (exon 5) on chromosome 21 and the ETO gene on chromosome 8 (exon 2), resulting in a AML1-ETO fusion transcript.  In general, these cases respond to chemotherapy and have high complete remission rates; although the presence of CD56 and KIT mutations confer poorer prognosis.

The t(8,21)(q22;q22) translocation is one of the most common chromosomal translocations in acute myeloid leukemia (AML), accounting for 40% of pediatric leukemia classified as AML M2