PML/RARA

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) genetically characterized by the t(15;17)(q22;q11) translocation. More than 99% of APL patients carry a translocation which results in the fusion of the retinoic acid receptor-alpha (RARα) gene on chromosome 17q and the PML gene on chromosome 15q. Two major transcripts are observed: an exon6^PML/exon3^RARA fusion or an exon3 ^PML/exon3 ^RARA fusion.